A Single Amino Acid Substitution in the Matrix Protein (M51R) of Vesicular Stomatitis New Jersey Virus Impairs Replication in Cultured Porcine Macrophages and Results in Significant Attenuation in Pigs

In this study, we explore the virulence of vesicular stomatitis New Jersey virus (VSNJV) in pigs and its potential relationship with the virus’s ability to modulate innate responses. For this purpose, we developed a mutant of the highly virulent strain NJ0612NME6, containing a single amino acid subs...

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Detalles Bibliográficos
Autores principales: Velazquez-Salinas, Lauro, Pauszek, Steven J., Holinka, Lauren G., Gladue, Douglas P., Rekant, Steven I., Bishop, Elizabeth A., Stenfeldt, Carolina, Verdugo-Rodriguez, Antonio, Borca, Manuel V., Arzt, Jonathan, Rodriguez, Luis L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299242/
https://www.ncbi.nlm.nih.gov/pubmed/32587580
http://dx.doi.org/10.3389/fmicb.2020.01123

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299242/
https://www.ncbi.nlm.nih.gov/pubmed/32587580
http://dx.doi.org/10.3389/fmicb.2020.01123

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