MxB sensitivity of HIV-1 is determined by a highly variable and dynamic capsid surface

The type one interferon induced restriction factor Myxovirus resistance B (MxB) restricts HIV-1 nuclear entry evidenced by inhibition of 2-LTR but not linear forms of viral DNA. The HIV-1 capsid is the key determinant of MxB sensitivity and cofactor binding defective HIV-1 capsid mutants P90A (defec...

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Detalles Bibliográficos
Autores principales: Miles, Richard J, Kerridge, Claire, Hilditch, Laura, Monit, Christopher, Jacques, David A, Towers, Greg J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Microbiology and Infectious Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299335/
https://www.ncbi.nlm.nih.gov/pubmed/32553106
http://dx.doi.org/10.7554/eLife.56910

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299335/
https://www.ncbi.nlm.nih.gov/pubmed/32553106
http://dx.doi.org/10.7554/eLife.56910

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