IMRAS—A clinical trial of mosquito-bite immunization with live, radiation-attenuated P. falciparum sporozoites: Impact of immunization parameters on protective efficacy and generation of a repository of immunologic reagents

BACKGROUND: Immunization with radiation-attenuated sporozoites (RAS) by mosquito bite provides >90% sterile protection against Plasmodium falciparum (Pf) malaria in humans. RAS invade hepatocytes but do not replicate. CD8+ T cells recognizing parasite-derived peptides on the surface of infected h...

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Detalles Bibliográficos
Autores principales: Hickey, Bradley, Teneza-Mora, Nimfa, Lumsden, Joanne, Reyes, Sharina, Sedegah, Martha, Garver, Lindsey, Hollingdale, Michael R., Banania, Jo Glenna, Ganeshan, Harini, Dowler, Megan, Reyes, Anatalio, Tamminga, Cindy, Singer, Alexandra, Simmons, Alicia, Belmonte, Maria, Belmonte, Arnel, Huang, Jun, Inoue, Sandra, Velasco, Rachel, Abot, Steve, Vasquez, Carlos S., Guzman, Ivelese, Wong, Mimi, Twomey, Patrick, Wojnarski, Mariusz, Moon, James, Alcorta, Yolanda, Maiolatesi, Santina, Spring, Michele, Davidson, Silas, Chaudhury, Sidhartha, Villasante, Eileen, Richie, Thomas L., Epstein, Judith E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299375/
https://www.ncbi.nlm.nih.gov/pubmed/32555601
http://dx.doi.org/10.1371/journal.pone.0233840

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299375/
https://www.ncbi.nlm.nih.gov/pubmed/32555601
http://dx.doi.org/10.1371/journal.pone.0233840

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