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BRM-SWI/SNF chromatin remodeling complex enables functional telomeres by promoting co-expression of TRF2 and TRF1

TRF2 and TRF1 are a key component in shelterin complex that associates with telomeric DNA and protects chromosome ends. BRM is a core ATPase subunit of SWI/SNF chromatin remodeling complex. Whether and how BRM-SWI/SNF complex is engaged in chromatin end protection by telomeres is unknown. Here, we r...

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Detalles Bibliográficos
Autores principales: Wu, Shu, Ge, Yuanlong, Li, Xiaocui, Yang, Yiding, Zhou, Haoxian, Lin, Kaixuan, Zhang, Zepeng, Zhao, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299400/
https://www.ncbi.nlm.nih.gov/pubmed/32502208
http://dx.doi.org/10.1371/journal.pgen.1008799