Targeting miR-27a/VE-cadherin interactions rescues cerebral cavernous malformations in mice

Cerebral cavernous malformations (CCMs) are vascular lesions predominantly developing in the central nervous system (CNS), with no effective treatments other than surgery. Loss-of-function mutation in CCM1/krev interaction trapped 1 (KRIT1), CCM2, or CCM3/programmed cell death 10 (PDCD10) causes les...

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Detalles Bibliográficos
Autores principales: Li, Jia, Zhao, Yang, Choi, Jaesung, Ting, Ka Ka, Coleman, Paul, Chen, Jinbiao, Cogger, Victoria C., Wan, Li, Shi, Zhongsong, Moller, Thorleif, Zheng, Xiangjian, Vadas, Mathew A., Gamble, Jennifer R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299406/
https://www.ncbi.nlm.nih.gov/pubmed/32502201
http://dx.doi.org/10.1371/journal.pbio.3000734

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299406/
https://www.ncbi.nlm.nih.gov/pubmed/32502201
http://dx.doi.org/10.1371/journal.pbio.3000734

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