An orthogonally regulatable DNA nanodevice for spatiotemporally controlled biorecognition and tumor treatment

Despite the potential of nanodevices for intelligent drug delivery, it remains challenging to develop controllable therapeutic devices with high spatial-temporal selectivity. Here, we report a DNA nanodevice that can achieve tumor recognition and treatment with improved spatiotemporal precision unde...

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Autores principales: Di, Zhenghan, Liu, Bei, Zhao, Jian, Gu, Zhanjun, Zhao, Yuliang, Li, Lele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299621/
https://www.ncbi.nlm.nih.gov/pubmed/32596466
http://dx.doi.org/10.1126/sciadv.aba9381
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author Di, Zhenghan
Liu, Bei
Zhao, Jian
Gu, Zhanjun
Zhao, Yuliang
Li, Lele
author_facet Di, Zhenghan
Liu, Bei
Zhao, Jian
Gu, Zhanjun
Zhao, Yuliang
Li, Lele
author_sort Di, Zhenghan
collection PubMed
description Despite the potential of nanodevices for intelligent drug delivery, it remains challenging to develop controllable therapeutic devices with high spatial-temporal selectivity. Here, we report a DNA nanodevice that can achieve tumor recognition and treatment with improved spatiotemporal precision under the regulation of orthogonal near-infrared (NIR) light. The nanodevice is built by combining an ultraviolet (UV) light–activatable aptamer module and a photosensitizer (PS) with up-conversion nanoparticle (UCNP) that enables the operation of the nanodevice with deep tissue–penetrable NIR light. The UCNPs can convert two distinct NIR excitations into orthogonal UV and green emissions for programmable photoactivation of the aptamer modules and PSs, respectively, allowing spatiotemporally controlled target recognition and photodynamic antitumor effect. Furthermore, when combined with immune checkpoint blockade therapy, the nanodevice results in regression of untreated distant tumors. This work provides a new approach for regulation of diagnostic and therapeutic activity at the right time and place.
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spelling pubmed-72996212020-06-25 An orthogonally regulatable DNA nanodevice for spatiotemporally controlled biorecognition and tumor treatment Di, Zhenghan Liu, Bei Zhao, Jian Gu, Zhanjun Zhao, Yuliang Li, Lele Sci Adv Research Articles Despite the potential of nanodevices for intelligent drug delivery, it remains challenging to develop controllable therapeutic devices with high spatial-temporal selectivity. Here, we report a DNA nanodevice that can achieve tumor recognition and treatment with improved spatiotemporal precision under the regulation of orthogonal near-infrared (NIR) light. The nanodevice is built by combining an ultraviolet (UV) light–activatable aptamer module and a photosensitizer (PS) with up-conversion nanoparticle (UCNP) that enables the operation of the nanodevice with deep tissue–penetrable NIR light. The UCNPs can convert two distinct NIR excitations into orthogonal UV and green emissions for programmable photoactivation of the aptamer modules and PSs, respectively, allowing spatiotemporally controlled target recognition and photodynamic antitumor effect. Furthermore, when combined with immune checkpoint blockade therapy, the nanodevice results in regression of untreated distant tumors. This work provides a new approach for regulation of diagnostic and therapeutic activity at the right time and place. American Association for the Advancement of Science 2020-06-17 /pmc/articles/PMC7299621/ /pubmed/32596466 http://dx.doi.org/10.1126/sciadv.aba9381 Text en Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (http://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Research Articles
Di, Zhenghan
Liu, Bei
Zhao, Jian
Gu, Zhanjun
Zhao, Yuliang
Li, Lele
An orthogonally regulatable DNA nanodevice for spatiotemporally controlled biorecognition and tumor treatment
title An orthogonally regulatable DNA nanodevice for spatiotemporally controlled biorecognition and tumor treatment
title_full An orthogonally regulatable DNA nanodevice for spatiotemporally controlled biorecognition and tumor treatment
title_fullStr An orthogonally regulatable DNA nanodevice for spatiotemporally controlled biorecognition and tumor treatment
title_full_unstemmed An orthogonally regulatable DNA nanodevice for spatiotemporally controlled biorecognition and tumor treatment
title_short An orthogonally regulatable DNA nanodevice for spatiotemporally controlled biorecognition and tumor treatment
title_sort orthogonally regulatable dna nanodevice for spatiotemporally controlled biorecognition and tumor treatment
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299621/
https://www.ncbi.nlm.nih.gov/pubmed/32596466
http://dx.doi.org/10.1126/sciadv.aba9381
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