An orthogonally regulatable DNA nanodevice for spatiotemporally controlled biorecognition and tumor treatment
Despite the potential of nanodevices for intelligent drug delivery, it remains challenging to develop controllable therapeutic devices with high spatial-temporal selectivity. Here, we report a DNA nanodevice that can achieve tumor recognition and treatment with improved spatiotemporal precision unde...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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American Association for the Advancement of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299621/ https://www.ncbi.nlm.nih.gov/pubmed/32596466 http://dx.doi.org/10.1126/sciadv.aba9381 |
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author | Di, Zhenghan Liu, Bei Zhao, Jian Gu, Zhanjun Zhao, Yuliang Li, Lele |
author_facet | Di, Zhenghan Liu, Bei Zhao, Jian Gu, Zhanjun Zhao, Yuliang Li, Lele |
author_sort | Di, Zhenghan |
collection | PubMed |
description | Despite the potential of nanodevices for intelligent drug delivery, it remains challenging to develop controllable therapeutic devices with high spatial-temporal selectivity. Here, we report a DNA nanodevice that can achieve tumor recognition and treatment with improved spatiotemporal precision under the regulation of orthogonal near-infrared (NIR) light. The nanodevice is built by combining an ultraviolet (UV) light–activatable aptamer module and a photosensitizer (PS) with up-conversion nanoparticle (UCNP) that enables the operation of the nanodevice with deep tissue–penetrable NIR light. The UCNPs can convert two distinct NIR excitations into orthogonal UV and green emissions for programmable photoactivation of the aptamer modules and PSs, respectively, allowing spatiotemporally controlled target recognition and photodynamic antitumor effect. Furthermore, when combined with immune checkpoint blockade therapy, the nanodevice results in regression of untreated distant tumors. This work provides a new approach for regulation of diagnostic and therapeutic activity at the right time and place. |
format | Online Article Text |
id | pubmed-7299621 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-72996212020-06-25 An orthogonally regulatable DNA nanodevice for spatiotemporally controlled biorecognition and tumor treatment Di, Zhenghan Liu, Bei Zhao, Jian Gu, Zhanjun Zhao, Yuliang Li, Lele Sci Adv Research Articles Despite the potential of nanodevices for intelligent drug delivery, it remains challenging to develop controllable therapeutic devices with high spatial-temporal selectivity. Here, we report a DNA nanodevice that can achieve tumor recognition and treatment with improved spatiotemporal precision under the regulation of orthogonal near-infrared (NIR) light. The nanodevice is built by combining an ultraviolet (UV) light–activatable aptamer module and a photosensitizer (PS) with up-conversion nanoparticle (UCNP) that enables the operation of the nanodevice with deep tissue–penetrable NIR light. The UCNPs can convert two distinct NIR excitations into orthogonal UV and green emissions for programmable photoactivation of the aptamer modules and PSs, respectively, allowing spatiotemporally controlled target recognition and photodynamic antitumor effect. Furthermore, when combined with immune checkpoint blockade therapy, the nanodevice results in regression of untreated distant tumors. This work provides a new approach for regulation of diagnostic and therapeutic activity at the right time and place. American Association for the Advancement of Science 2020-06-17 /pmc/articles/PMC7299621/ /pubmed/32596466 http://dx.doi.org/10.1126/sciadv.aba9381 Text en Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (http://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
spellingShingle | Research Articles Di, Zhenghan Liu, Bei Zhao, Jian Gu, Zhanjun Zhao, Yuliang Li, Lele An orthogonally regulatable DNA nanodevice for spatiotemporally controlled biorecognition and tumor treatment |
title | An orthogonally regulatable DNA nanodevice for spatiotemporally controlled biorecognition and tumor treatment |
title_full | An orthogonally regulatable DNA nanodevice for spatiotemporally controlled biorecognition and tumor treatment |
title_fullStr | An orthogonally regulatable DNA nanodevice for spatiotemporally controlled biorecognition and tumor treatment |
title_full_unstemmed | An orthogonally regulatable DNA nanodevice for spatiotemporally controlled biorecognition and tumor treatment |
title_short | An orthogonally regulatable DNA nanodevice for spatiotemporally controlled biorecognition and tumor treatment |
title_sort | orthogonally regulatable dna nanodevice for spatiotemporally controlled biorecognition and tumor treatment |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299621/ https://www.ncbi.nlm.nih.gov/pubmed/32596466 http://dx.doi.org/10.1126/sciadv.aba9381 |
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