The effect of Sirt1 deficiency on Ca(2+) and Na(+) regulation in mouse ventricular myocytes

This study addressed the hypothesis that cardiac Sirtuin 1 (Sirt1) deficiency alters cardiomyocyte Ca(2+) and Na(+) regulation, leading to cardiac dysfunction and arrhythmogenesis. We used mice with cardiac‐specific Sirt1 knockout (Sirt1(−/−)). Sirt1(flox/flox) mice were served as control. Sirt1(−/−...

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Detalles Bibliográficos
Autores principales: Yang, Hsiang‐Yu, Lin, Feng‐Zhi, Yang, Hui‐Wen, Yu, Pei‐Ling, Huang, Shih‐Ming, Chen, Yao‐Chang, Tsai, Chien‐Sung, Lin, Chih‐Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299725/
https://www.ncbi.nlm.nih.gov/pubmed/32342656
http://dx.doi.org/10.1111/jcmm.15327

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299725/
https://www.ncbi.nlm.nih.gov/pubmed/32342656
http://dx.doi.org/10.1111/jcmm.15327

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