Cargando…

Smad3 gene C‐terminal phosphorylation site mutation aggravates CCl(4)‐induced inflammation in mice

The expression of C‐terminal phosphorylated Smad3 (pSmad3C) is down‐regulated with the progression of liver disease. Thus, we hypothesized that pSmad3C expression may be negatively related to liver disease. To develop novel therapeutic strategies, a suitable animal model is required that will allow...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ding, Hanyan, Fang, Meng, Gong, Yongfang, Li, Dong, Zhang, Chong, Wen, Guanghua, Wu, Chao, Yang, Jingjing, Yang, Yan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299733/ https://www.ncbi.nlm.nih.gov/pubmed/32406200 http://dx.doi.org/10.1111/jcmm.15385

Ejemplares similares

Indole-3-propionic Acid-aggravated CCl(4)-induced Liver Fibrosis via the TGF-β1/Smads Signaling Pathway
por: Liu, Fei, et al.
Publicado: (2021)

The Roles of CCR9/CCL25 in Inflammation and Inflammation-Associated Diseases
por: Wu, Xue, et al.
Publicado: (2021)

mTOR Overactivation in Mesenchymal cells Aggravates CCl(4)− Induced liver Fibrosis
por: Shan, Lanlan, et al.
Publicado: (2016)

Age-related CCL12 Aggravates Intracerebral Hemorrhage-induced Brain Injury via Recruitment of Macrophages and T Lymphocytes
por: Huang, Jiacheng, et al.
Publicado: (2020)

Extracellular matrix stiffness aggravates urethral stricture through Igfbp3/Smad pathway
por: Li, Kaixuan, et al.
Publicado: (2023)

Salvianolic acid B protects against acute and chronic liver injury by inhibiting Smad2C/L phosphorylation
por: Tao, Xiang-Ming, et al.
Publicado: (2021)

Spatially interacting phosphorylation sites and mutations in cancer
por: Huang, Kuan-lin, et al.
Publicado: (2021)

Identification of Epithelial-Mesenchymal Transition-related Target Genes Induced by the Mutation of Smad3 Linker Phosphorylation
por: Park, Sujin, et al.
Publicado: (2018)

Identification of Epithelial-Mesenchymal Transition-related Target Genes Induced by the Mutation of Smad3 Linker Phosphorylation
por: Park, Sujin, et al.
Publicado: (2018)

Bacterial translocation aggravates CCl(4)-induced liver cirrhosis by regulating CD4(+) T cells in rats
por: Shi, Haiyan, et al.
Publicado: (2017)

Smad7 Deficiency in Myeloid Cells Does Not Affect Liver Injury, Inflammation or Fibrosis after Chronic CCl(4) Exposure in Mice
por: Unrau, Ludmilla, et al.
Publicado: (2021)

Mutation of Androgen Receptor N-Terminal Phosphorylation Site Tyr-267 Leads to Inhibition of Nuclear Translocation and DNA Binding
por: Karaca, Mehmet, et al.
Publicado: (2015)

TGF-Beta Induced Erk Phosphorylation of Smad Linker Region Regulates Smad Signaling
por: Hough, Chris, et al.
Publicado: (2012)

The Deficiency of Indoleamine 2,3-Dioxygenase Aggravates the CCl(4)-Induced Liver Fibrosis in Mice
por: Ogiso, Hideyuki, et al.
Publicado: (2016)

Hepatic Deletion of Smad7 in Mouse Leads to Spontaneous Liver Dysfunction and Aggravates Alcoholic Liver Injury
por: Zhu, Lu, et al.
Publicado: (2011)

Zinc accumulation aggravates cerebral ischemia/reperfusion injury by promoting inflammation
por: Li, Wei, et al.
Publicado: (2023)

Endoglin aggravates peritoneal fibrosis by regulating the activation of TGF-β/ALK/Smads signaling
por: Huang, Qian, et al.
Publicado: (2022)

Aggravation of TGFβ1-Smad Pathway and Autoimmune Myocarditis by Fungicide (Tebuconazole) Exposure
por: Marino, Ylenia, et al.
Publicado: (2023)

Docetaxel-Aggravated Psoriasis
por: Yang, Seungkeol, et al.
Publicado: (2019)

Phosphorylated Smad2 in Advanced Stage Gastric Carcinoma
por: Shinto, Osamu, et al.
Publicado: (2010)

CCL24 Protects Renal Function by Controlling Inflammation in Podocytes
por: Wang, Youdi, et al.
Publicado: (2021)

Imbalanced Dermic Microbiome Aggravates Inflammation in Toenail Paronychia
por: Li, Ying, et al.
Publicado: (2021)

Interaction of microRNA-21/145 and Smad3 domain-specific phosphorylation in hepatocellular carcinoma
por: Wang, Ji Yu, et al.
Publicado: (2017)

Melatonin attenuates hypoxia-induced epithelial-mesenchymal transition and cell aggressive via Smad7/ CCL20 in glioma
por: Chen, Xueran, et al.
Publicado: (2017)

TGF-β1 blockade of microglial chemotaxis toward Aβ aggregates involves SMAD signaling and down-regulation of CCL5
por: Huang, Wei-Chao, et al.
Publicado: (2010)

MyoD phosphorylation on multiple C terminal sites regulates myogenic conversion activity
por: Hardwick, Laura J.A., et al.
Publicado: (2016)

Thyrotropin aggravates atherosclerosis by promoting macrophage inflammation in plaques
por: Yang, Chongbo, et al.
Publicado: (2019)

Mucin1 promotes the migration and invasion of hepatocellular carcinoma cells via JNK-mediated phosphorylation of Smad2 at the C-terminal and linker regions
por: Wang, Juan, et al.
Publicado: (2015)

Diabetes aggravates renal ischemia and reperfusion injury in rats by exacerbating oxidative stress, inflammation, and apoptosis
por: Gong, Dao-Jing, et al.
Publicado: (2019)

sNASP Mutation Aggravates to the TLR4-Mediated Inflammation in SLE by TAK1 Pathway
por: Bao, Yatao, et al.
Publicado: (2023)

Antifibrotic Effect of Smad Decoy Oligodeoxynucleotide in a CCl(4)-Induced Hepatic Fibrosis Animal Model
por: Gwon, Mi-Gyeong, et al.
Publicado: (2018)

Acute Liver Injury after CCl(4) Administration Is Independent of Smad7 Expression in Myeloid Cells
por: Endig, Jessica, et al.
Publicado: (2019)

miR-127 aggravates myocardial failure by promoting the TGF-β1/Smad3 signaling
por: Xu, Hainian, et al.
Publicado: (2018)

Interleukin-19 Aggravates Pulmonary Fibrosis via Activating Fibroblast through TGF-β/Smad Pathway
por: Wang, Yu, et al.
Publicado: (2022)

In Vivo Disruption of TGF-β Signaling by Smad7 in Airway Epithelium Alleviates Allergic Asthma but Aggravates Lung Carcinogenesis in Mouse
por: Luo, Xiaolin, et al.
Publicado: (2010)

Novel Interplay Between Smad1 and Smad3 Phosphorylation via AGE Regulates the Progression of Diabetic Nephropathy
por: Ono, Hiroyuki, et al.
Publicado: (2018)

Inhalation of Carbon Black Nanoparticles Aggravates Pulmonary Inflammation in Mice
por: Saputra, Devina, et al.
Publicado: (2014)

The polysaccharides from Grifola frondosa attenuate CCl(4)-induced hepatic fibrosis in rats via the TGF-β/Smad signaling pathway
por: Li, Chao, et al.
Publicado: (2019)

Novel PKCα-mediated phosphorylation site(s) on cofilin and their potential role in terminating histamine release
por: Sakuma, Megumi, et al.
Publicado: (2012)

Mutational Analysis of the Terminal Protein Tpg of Streptomyces Chromosomes: Identification of the Deoxynucleotidylation Site
por: Yang, Chien-Chin, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_4nd9g3m8m9ukkudro5hq4jha25