Efficient polygenic risk scores for biobank scale data by exploiting phenotypes from inferred relatives

Polygenic risk scores are emerging as a potentially powerful tool to predict future phenotypes of target individuals, typically using unrelated individuals, thereby devaluing information from relatives. Here, for 50 traits from the UK Biobank data, we show that a design of 5,000 individuals with fir...

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Detalles Bibliográficos
Autores principales: Truong, Buu, Zhou, Xuan, Shin, Jisu, Li, Jiuyong, van der Werf, Julius H. J., Le, Thuc D., Lee, S. Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299943/
https://www.ncbi.nlm.nih.gov/pubmed/32555176
http://dx.doi.org/10.1038/s41467-020-16829-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299943/
https://www.ncbi.nlm.nih.gov/pubmed/32555176
http://dx.doi.org/10.1038/s41467-020-16829-x

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