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Efficient polygenic risk scores for biobank scale data by exploiting phenotypes from inferred relatives
Polygenic risk scores are emerging as a potentially powerful tool to predict future phenotypes of target individuals, typically using unrelated individuals, thereby devaluing information from relatives. Here, for 50 traits from the UK Biobank data, we show that a design of 5,000 individuals with fir...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299943/ https://www.ncbi.nlm.nih.gov/pubmed/32555176 http://dx.doi.org/10.1038/s41467-020-16829-x |