Cargando…

Fibronectin extra domain A (FN-EDA) elevates intraocular pressure through Toll-like receptor 4 signaling

Elevated intraocular pressure (IOP) is a major risk factor for the development and progression of primary open angle glaucoma and is due to trabecular meshwork (TM) damage, which leads to impaired aqueous humor outflow. Here, we explore a novel molecular mechanism involved in glaucomatous TM damage....

Descripción completa

Detalles Bibliográficos
Autores principales:	Roberts, Amanda L., Mavlyutov, Timur A., Perlmutter, Tanisha E., Curry, Stacy M., Harris, Sherri L., Chauhan, Anil K., McDowell, Colleen M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299944/ https://www.ncbi.nlm.nih.gov/pubmed/32555351 http://dx.doi.org/10.1038/s41598-020-66756-6

Ejemplares similares

Fibronectin extra domain A (FN-EDA) causes glaucomatous trabecular meshwork, retina, and optic nerve damage in mice
por: Mavlyutov, Timur A., et al.
Publicado: (2022)

Disruption of fibronectin fibrillogenesis affects intraocular pressure (IOP) in BALB/cJ mice
por: Faralli, Jennifer A., et al.
Publicado: (2020)

Regulated splicing of the fibronectin EDA exon is essential for proper skin wound healing and normal lifespan
por: Muro, Andrés F., et al.
Publicado: (2003)

EDA fibronectin–TLR4 axis sustains megakaryocyte expansion and inflammation in bone marrow fibrosis
por: Malara, Alessandro, et al.
Publicado: (2019)

EDA-Containing Fibronectin Increases Proliferation of Embryonic Stem Cells
por: Losino, Noelia, et al.
Publicado: (2013)

Keloid Pathogenesis: Potential Role of Cellular Fibronectin with the EDA Domain
por: Andrews, Jonathan P., et al.
Publicado: (2015)

Analysis of Soluble Molecular Fibronectin-Fibrin Complexes and EDA-Fibronectin Concentration in Plasma of Patients with Atherosclerosis
por: Lemańska-Perek, Anna, et al.
Publicado: (2016)

Implications for Collagen Binding from the Crystallographic Structure of Fibronectin (6)FnI(1–2)FnII(7)FnI
por: Erat, Michèle C., et al.
Publicado: (2010)

Modulation of Cell-adhesive Activity of Fibronectin by the Alternatively Spliced EDA Segment
por: Manabe, Ri-ichiroh, et al.
Publicado: (1997)

A novel variant in FN1 in a family with fibronectin glomerulopathy
por: Aslam, Nabeel, et al.
Publicado: (2019)

TLR4 signaling modulates extracellular matrix production in the lamina cribrosa
por: Geiduschek, Emma K., et al.
Publicado: (2022)

Hsp90 Binds Directly to Fibronectin (FN) and Inhibition Reduces the Extracellular Fibronectin Matrix in Breast Cancer Cells
por: Hunter, Morgan C., et al.
Publicado: (2014)

EDA-Fibronectin Originating from Osteoblasts Inhibits the Immune Response against Cancer
por: Rossnagl, Stephanie, et al.
Publicado: (2016)

The Multivalent Role of Fibronectin-Binding Proteins A and B (FnBPA and FnBPB) of Staphylococcus aureus in Host Infections
por: Speziale, Pietro, et al.
Publicado: (2020)

Regulation of the Innate Immune Response by Fibronectin: Synergism between the III-1 and EDA Domains
por: Kelsh, Rhiannon, et al.
Publicado: (2014)

FN-EDA mediates angiogenesis of hepatic fibrosis via integrin-VEGFR2 in a CD63 synergetic manner
por: Su, Xiaonan, et al.
Publicado: (2020)

Fibronectin EDA and CpG synergize to enhance antigen-specific Th1 and cytotoxic responses
por: Julier, Ziad, et al.
Publicado: (2016)

The RNA binding protein Quaking represses splicing of the Fibronectin EDA exon and downregulates the interferon response
por: Liao, Kuo-Chieh, et al.
Publicado: (2021)

Cellular Fibronectin Containing Extra Domain A Causes Insulin Resistance via Toll-like Receptor 4
por: Rajak, Sangam, et al.
Publicado: (2020)

Quantification of Fibronectin 1 (FN1) splice variants, including two novel ones, and analysis of integrins as candidate FN1 receptors in bovine preimplantation embryos
por: Goossens, Karen, et al.
Publicado: (2009)

Design and Evaluation of a Polypeptide That Mimics the Integrin Binding Site for EDA Fibronectin to Block Profibrotic Cell Activity
por: Zhang, Lin, et al.
Publicado: (2021)

Toll-Like Receptor 4 Signaling in the Trabecular Meshwork
por: Mzyk, Philip, et al.
Publicado: (2022)

Evidence for Steric Regulation of Fibrinogen Binding to Staphylococcus aureus Fibronectin-binding Protein A (FnBPA)
por: Stemberk, Vaclav, et al.
Publicado: (2014)

Fibronectin containing alternatively spliced extra domain A interacts at the central and c-terminal domain of Toll-like receptor-4
por: Gupta, Shubhangi, et al.
Publicado: (2022)

A child with genetic FN1 mutation in the absence of classic glomerulopathy with fibronectin deposits(GFND) findings on biopsy
por: Yang, Xiao-qing, et al.
Publicado: (2022)

Structure of unliganded membrane-proximal domains FN4-FN5-FN6 of DCC
por: Finci, Lorenzo I., et al.
Publicado: (2017)

Aerobic Oxidative EDA Catalysis: Synthesis of Tetrahydroquinolines Using an Organocatalytic EDA Active Acceptor
por: Runemark, August, et al.
Publicado: (2022)

Staphylococcus aureus Keratinocyte Invasion Is Dependent upon Multiple High-Affinity Fibronectin-Binding Repeats within FnBPA
por: Edwards, Andrew M., et al.
Publicado: (2011)

BMP and Activin Membrane Bound Inhibitor Regulates the Extracellular Matrix in the Trabecular Meshwork
por: Hernandez, Humberto, et al.
Publicado: (2018)

Final report of the ITER EDA
por: International Atomic Energy Agency. Vienna
Publicado: (2001)

Expression, refolding and spectroscopic characterization of fibronectin type III (FnIII)-homology domains derived from human fibronectin leucine rich transmembrane protein (FLRT)-1, -2, and -3
por: Yang, Lila, et al.
Publicado: (2017)

Myo5b Transports Fibronectin-Containing Vesicles and Facilitates FN1 Secretion from Human Pleural Mesothelial Cells
por: Sakai, Tsuyoshi, et al.
Publicado: (2022)

Crosstalk Between Transforming Growth Factor Beta-2 and Toll-Like Receptor 4 in the Trabecular Meshwork
por: Hernandez, Humberto, et al.
Publicado: (2017)

Essential electronic design automation (EDA)
por: Birnbaum, Mark
Publicado: (2004)

Fibronectin Extra Domain A Promotes Liver Sinusoid Repair following Hepatectomy
por: Sackey-Aboagye, Bridget, et al.
Publicado: (2016)

FN1 mRNA 3'-UTR supersedes traditional fibronectin 1 in facilitating the invasion and metastasis of gastric cancer through the FN1 3'-UTR-let-7i-5p-THBS1 axis
por: Pan, Siwei, et al.
Publicado: (2023)

Targeting the extra domain A of fibronectin for cancer therapy with CAR-T cells
por: Martín-Otal, Celia, et al.
Publicado: (2022)

Synovial chondromatosis and soft tissue chondroma: extra-osseous cartilaginous tumours defined by FN1 gene rearrangement
por: Amary, Fernanda, et al.
Publicado: (2019)

Elevated plasma EDA fibronectin in primary myelofibrosis is determined by high allele burden of JAK2V617F mutation and strongly predicts splenomegaly progression
por: Malara, Alessandro, et al.
Publicado: (2022)

Fibronectin (FN) cooperated with TLR2/TLR4 receptor to promote innate immune responses of macrophages via binding to integrin β1
por: Fei, Dongsheng, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_28s2ffdkkuebgedengp3gu0odc