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Multicellular 3D Neurovascular Unit Model for Assessing Hypoxia and Neuroinflammation Induced Blood-Brain Barrier Dysfunction
The blood-brain barrier (BBB) is a dynamic component of the brain-vascular interface that maintains brain homeostasis and regulates solute permeability into brain tissue. The expression of tight junction proteins between adjacent endothelial cells and the presence of efflux proteins prevents entry o...
Autores principales: | Nzou, Goodwell, Wicks, Robert T., VanOstrand, Nicole R., Mekky, Gehad A., Seale, Stephanie A., EL-Taibany, Aya, Wicks, Elizabeth E., Nechtman, Carl M., Marotte, Eric J., Makani, Vishruti S., Murphy, Sean V., Seeds, M. C., Jackson, John D., Atala, Anthony J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299970/ https://www.ncbi.nlm.nih.gov/pubmed/32555384 http://dx.doi.org/10.1038/s41598-020-66487-8 |
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