Theoretical insights on helix repacking as the origin of P-glycoprotein promiscuity

P-glycoprotein (P-gp, ABCB1) overexpression is, currently, one of the most important multidrug resistance (MDR) mechanisms in tumor cells. Thus, modulating drug efflux by P-gp has become one of the most promising approaches to overcome MDR in cancer. Yet, more insights on the molecular basis of drug...

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Detalles Bibliográficos
Autores principales: Bonito, Cátia A., Ferreira, Ricardo J., Ferreira, Maria-José. U., Gillet, Jean-Pierre, Cordeiro, M. Natália D. S., dos Santos, Daniel J. V. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300024/
https://www.ncbi.nlm.nih.gov/pubmed/32555203
http://dx.doi.org/10.1038/s41598-020-66587-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300024/
https://www.ncbi.nlm.nih.gov/pubmed/32555203
http://dx.doi.org/10.1038/s41598-020-66587-5

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