PTEN activation contributes to neuronal and synaptic engulfment by microglia in tauopathy

Phosphatase and tensin homolog (PTEN) regulates synaptic density in development; however, whether PTEN also regulates synapse loss in a neurodegenerative disorder such as frontotemporal lobar degeneration with Tau deposition (FTLD-Tau) has not been explored. Here, we found that pathological Tau prom...

Descripción completa

Detalles Bibliográficos
Autores principales: Benetatos, Joseph, Bennett, Rachel E., Evans, Harrison T., Ellis, Sevannah A., Hyman, Bradley T., Bodea, Liviu-Gabriel, Götz, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300099/
https://www.ncbi.nlm.nih.gov/pubmed/32236736
http://dx.doi.org/10.1007/s00401-020-02151-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300099/
https://www.ncbi.nlm.nih.gov/pubmed/32236736
http://dx.doi.org/10.1007/s00401-020-02151-9

Ejemplares similares