Old World Monkeys are less than ideal transplantation models for testing pig organs lacking three carbohydrate antigens (Triple-Knockout)

Triple-knockout (TKO) pigs (with added protective human transgenes) are likely to be optimal sources of organs for clinical organ xenotransplantation because many humans have minimal or no natural antibody to TKO pig cells. However, Old World monkeys (OWMs) have naturally-existing antibodies directe...

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Detalles Bibliográficos
Autores principales: Yamamoto, Takayuki, Iwase, Hayato, Patel, Diyan, Jagdale, Abhijit, Ayares, David, Anderson, Douglas, Eckhoff, Devin E., Cooper, David K. C., Hara, Hidetaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300119/
https://www.ncbi.nlm.nih.gov/pubmed/32555507
http://dx.doi.org/10.1038/s41598-020-66311-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300119/
https://www.ncbi.nlm.nih.gov/pubmed/32555507
http://dx.doi.org/10.1038/s41598-020-66311-3

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