Activation of STING by cGAMP Regulates MDSCs to Suppress Tumor Metastasis via Reversing Epithelial-Mesenchymal Transition

The role of cGAMP stimulating cGAS-cGAMP-STING-IRF3 pathway to inhibit tumor growth was well-established. Herein, the efficiency and pharmacological mechanism of cGAMP on regulating tumor metastasis was investigated. The effects of cGAMP regulating CD8(+) T cells and myeloid-derived suppressor cells...

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Detalles Bibliográficos
Autores principales: Cheng, Hao, Xu, Qiming, Lu, Xing, Yuan, Hong, Li, Tiejun, Zhang, Yuefan, Tan, Xiangshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300176/
https://www.ncbi.nlm.nih.gov/pubmed/32596152
http://dx.doi.org/10.3389/fonc.2020.00896

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300176/
https://www.ncbi.nlm.nih.gov/pubmed/32596152
http://dx.doi.org/10.3389/fonc.2020.00896

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