The taming of PARP1 and its impact on NAD(+) metabolism

BACKGROUND: Poly-ADP-ribose polymerases (PARPs) are key mediators of cellular stress response. They are intimately linked to cellular metabolism through the consumption of NAD(+). PARP1/ARTD1 in the nucleus is the major NAD(+) consuming activity and plays a key role in maintaining genomic integrity....

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Detalles Bibliográficos
Autores principales: Hurtado-Bagès, Sarah, Knobloch, Gunnar, Ladurner, Andreas G., Buschbeck, Marcus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300387/
https://www.ncbi.nlm.nih.gov/pubmed/32199820
http://dx.doi.org/10.1016/j.molmet.2020.01.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300387/
https://www.ncbi.nlm.nih.gov/pubmed/32199820
http://dx.doi.org/10.1016/j.molmet.2020.01.014

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