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The taming of PARP1 and its impact on NAD(+) metabolism
BACKGROUND: Poly-ADP-ribose polymerases (PARPs) are key mediators of cellular stress response. They are intimately linked to cellular metabolism through the consumption of NAD(+). PARP1/ARTD1 in the nucleus is the major NAD(+) consuming activity and plays a key role in maintaining genomic integrity....
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300387/ https://www.ncbi.nlm.nih.gov/pubmed/32199820 http://dx.doi.org/10.1016/j.molmet.2020.01.014 |