Tight expression regulation of senataxin, linked to motor neuron disease and ataxia, is required to avert cell-cycle block and nucleolus disassembly

The Senataxin (SETX) protein exhibits strong sequence conservation with the helicase domain of the yeast protein Sen1p, and recessive SETX mutations cause a severe ataxia, known as Ataxia with Oculomotor Apraxia type 2, while dominant SETX mutations cause Amyotrophic Lateral Sclerosis type 4. SETX i...

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Detalles Bibliográficos
Autores principales: Bennett, Craig L., Sopher, Bryce L., La Spada, Albert R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301172/
https://www.ncbi.nlm.nih.gov/pubmed/32577562
http://dx.doi.org/10.1016/j.heliyon.2020.e04165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301172/
https://www.ncbi.nlm.nih.gov/pubmed/32577562
http://dx.doi.org/10.1016/j.heliyon.2020.e04165

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