Cargando…

Proteomic Profile of Mouse Brain Aging Contributions to Mitochondrial Dysfunction, DNA Oxidative Damage, Loss of Neurotrophic Factor, and Synaptic and Ribosomal Proteins

The deleterious effects of aging on the brain remain to be fully elucidated. In the present study, proteomic changes of young (4-month) and aged (16-month) B6129SF2/J male mouse hippocampus and cerebral cortex were investigated by using nano liquid chromatography tandem mass spectrometry (NanoLC-ESI...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Yingchao, Yu, Haitao, Chen, Chongyang, Li, Shupeng, Zhang, Zaijun, Xu, Hua, Zhu, Feiqi, Liu, Jianjun, Spencer, Peter S., Dai, Zhongliang, Yang, Xifei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301248/ https://www.ncbi.nlm.nih.gov/pubmed/32587661 http://dx.doi.org/10.1155/2020/5408452

Ejemplares similares

Dauricine Attenuates Spatial Memory Impairment and Alzheimer-Like Pathologies by Enhancing Mitochondrial Function in a Mouse Model of Alzheimer's Disease
por: Chen, Chongyang, et al.
Publicado: (2021)

Proteomic analysis reveals the potential neuroprotective effects of tetramethylpyrazine dimer in neuro2a/APPswe cells
por: Lin, Xiaoyi, et al.
Publicado: (2019)

Multiomics analysis of human peripheral blood reveals marked molecular profiling changes caused by one night of sleep deprivation
por: Chen, Chongyang, et al.
Publicado: (2023)

Mitochondrial Molecular Abnormalities Revealed by Proteomic Analysis of Hippocampal Organelles of Mice Triple Transgenic for Alzheimer Disease
por: Yu, Haitao, et al.
Publicado: (2018)

R13 preserves motor performance in SOD1(G93A) mice by improving mitochondrial function
por: Li, Xiao, et al.
Publicado: (2021)

TRPC1 Deletion Causes Striatal Neuronal Cell Apoptosis and Proteomic Alterations in Mice
por: Wang, Dian, et al.
Publicado: (2018)

The Isoquinoline Alkaloid Dauricine Targets Multiple Molecular Pathways to Ameliorate Alzheimer-Like Pathological Changes In Vitro
por: Liu, Pan, et al.
Publicado: (2018)

Tetramethylpyrazine Improves Cognitive Impairment and Modifies the Hippocampal Proteome in Two Mouse Models of Alzheimer's Disease
por: Huang, Xianfeng, et al.
Publicado: (2021)

The Prenylflavonoid Xanthohumol Reduces Alzheimer-Like Changes and Modulates Multiple Pathogenic Molecular Pathways in the Neuro2a/APP(swe) Cell Model of AD
por: Huang, Xianfeng, et al.
Publicado: (2018)

Ultrasound with microbubbles improves memory, ameliorates pathology and modulates hippocampal proteomic changes in a triple transgenic mouse model of Alzheimer's disease
por: Shen, Yuanyuan, et al.
Publicado: (2020)

Ginsenoside Rg1 Ameliorates Behavioral Abnormalities and Modulates the Hippocampal Proteomic Change in Triple Transgenic Mice of Alzheimer's Disease
por: Nie, Lulin, et al.
Publicado: (2017)

Reconstructing the evolution of the mitochondrial ribosomal proteome
por: Smits, Paulien, et al.
Publicado: (2007)

Platelet biomarkers for a descending cognitive function: A proteomic approach
por: Yu, Haitao, et al.
Publicado: (2021)

Adiponectin deficiency accelerates brain aging via mitochondria-associated neuroinflammation
por: He, Kaiwu, et al.
Publicado: (2023)

Quantitative Proteomics of Synaptic and Nonsynaptic Mitochondria: Insights for Synaptic Mitochondrial Vulnerability
por: Stauch, Kelly L., et al.
Publicado: (2014)

Confinement induces oxidative damage and synaptic dysfunction in mice
por: Li, Nuomin, et al.
Publicado: (2022)

Proteomics Unravels Emodin Causes Liver Oxidative Damage Elicited by Mitochondrial Dysfunction
por: Zhang, Yinhuan, et al.
Publicado: (2020)

Neurotrophic Treatment Initiated During Early Postnatal Development Prevents the Alzheimer-Like Behavior and Synaptic Dysfunction
por: Wei, Wei, et al.
Publicado: (2021)

Evaluation of therapeutic effects of tetramethylpyrazine nitrone in Alzheimer’s disease mouse model and proteomics analysis
por: Zhou, Xinhua, et al.
Publicado: (2023)

Dysfunctional Mitochondrial Bioenergetics and Synaptic Degeneration in Alzheimer Disease
por: Tang, Jason, et al.
Publicado: (2019)

Adaptive changes in the neuronal proteome: mitochondrial energy production, endoplasmic reticulum stress, and ribosomal dysfunction in the cellular response to metabolic stress
por: Herrmann, Abigail G, et al.
Publicado: (2013)

Proteomic profiling of the mitochondrial ribosome identifies Atp25 as a composite mitochondrial precursor protein
por: Woellhaf, Michael W., et al.
Publicado: (2016)

Mitochondrial Ribosome Dysfunction in Human Alveolar Type II Cells in Emphysema
por: Karim, Loukmane, et al.
Publicado: (2022)

Memantine Improves Cognitive Function and Alters Hippocampal and Cortical Proteome in Triple Transgenic Mouse Model of Alzheimer's Disease
por: Zhou, Xinhua, et al.
Publicado: (2019)

Prevention of dendritic and synaptic deficits and cognitive impairment with a neurotrophic compound
por: Baazaoui, Narjes, et al.
Publicado: (2017)

Natural compounds targeting mitochondrial dysfunction: emerging therapeutics for target organ damage in hypertension
por: Liao, Xiaolin, et al.
Publicado: (2023)

Diabetes mellitus is associated with elevated urinary pyrrole markers of γ-diketones known to cause axonal neuropathy
por: Chen, Xiao, et al.
Publicado: (2020)

Ketones prevent synaptic dysfunction induced by mitochondrial respiratory complex inhibitors
por: Kim, Do Young, et al.
Publicado: (2010)

Berberine Alleviates Amyloid β-Induced Mitochondrial Dysfunction and Synaptic Loss
por: Zhao, Chunhui, et al.
Publicado: (2019)

Ribosome dysfunction in osteoarthritis
por: van den Akker, Guus G.H., et al.
Publicado: (2022)

Urinary nicotine metabolites are associated with cognitive impairment among the elderly in southern China
por: Huang, Chao, et al.
Publicado: (2023)

ERAL1 is associated with mitochondrial ribosome and elimination of ERAL1 leads to mitochondrial dysfunction and growth retardation
por: Uchiumi, Takeshi, et al.
Publicado: (2010)

Lutein/zeaxanthin isomers regulate neurotrophic factors and synaptic plasticity in trained rats
por: ORHAN, Cemal, et al.
Publicado: (2021)

Characterizing neurotrophic factor-induced synaptic growth in primary mouse neuronal cultures
por: He, Guiqin, et al.
Publicado: (2022)

Discovery of Novel Markers for Identifying Cognitive Decline Using Neuron-Derived Exosomes
por: Zhong, Jiacheng, et al.
Publicado: (2021)

Ginsenoside compound K reduces neuronal damage and improves neuronal synaptic dysfunction by targeting Aβ
por: Li, Na, et al.
Publicado: (2023)

Editorial: Mitochondrial Proteomics: Understanding Mitochondria Function and Dysfunction Through the Characterization of Their Proteome
por: Ferri, Alberto, et al.
Publicado: (2020)

How Ricin Damages the Ribosome
por: Grela, Przemysław, et al.
Publicado: (2019)

Mitochondrial Dysfunction and α-Synuclein Synaptic Pathology in Parkinson's Disease: Who's on First?
por: Zaltieri, Michela, et al.
Publicado: (2015)

Premature synaptic mitochondrial dysfunction in the hippocampus during aging contributes to memory loss
por: Olesen, Margrethe A., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_g70hdem27ps3ko72lokjnh3csl