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H-Bond Surrogate-Stabilized Shortest Single-Turn α-Helices: sp(2) Constraints and Residue Preferences for the Highest α-Helicities
[Image: see text] Short α-helical sequences of proteins fail to maintain their native conformation when taken out of their protein context. Several covalent constraints have been designed, including the covalent H-bond surrogate (HBS)—where a peptide backbone i + 4 → i H-bond is replaced by a covale...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301546/ https://www.ncbi.nlm.nih.gov/pubmed/32566857 http://dx.doi.org/10.1021/acsomega.0c01277 |