Identification of therapeutic targets from genetic association studies using hierarchical component analysis

BACKGROUND: Mapping disease-associated genetic variants to complex disease pathophysiology is a major challenge in translating findings from genome-wide association studies into novel therapeutic opportunities. The difficulty lies in our limited understanding of how phenotypic traits arise from non-...

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Detalles Bibliográficos
Autores principales: Lee, Hao-Chih, Ichikawa, Osamu, Glicksberg, Benjamin S., Divaraniya, Aparna A., Becker, Christine E., Agarwal, Pankaj, Dudley, Joel T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301559/
https://www.ncbi.nlm.nih.gov/pubmed/32565911
http://dx.doi.org/10.1186/s13040-020-00216-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301559/
https://www.ncbi.nlm.nih.gov/pubmed/32565911
http://dx.doi.org/10.1186/s13040-020-00216-9

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