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Identification of therapeutic targets from genetic association studies using hierarchical component analysis
BACKGROUND: Mapping disease-associated genetic variants to complex disease pathophysiology is a major challenge in translating findings from genome-wide association studies into novel therapeutic opportunities. The difficulty lies in our limited understanding of how phenotypic traits arise from non-...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301559/ https://www.ncbi.nlm.nih.gov/pubmed/32565911 http://dx.doi.org/10.1186/s13040-020-00216-9 |