Targeting the SARS-CoV-2 spike glycoprotein prefusion conformation: virtual screening and molecular dynamics simulations applied to the identification of potential fusion inhibitors

The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a renewed interest in studying the role of the spike S glycoprotein in regulating coronavirus infections in the natural host. Taking advantage of the cryo-electron microscopy structure of SARS-CoV-2 S trimer...

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Detalles Bibliográficos
Autores principales: Romeo, Alice, Iacovelli, Federico, Falconi, Mattia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301794/
https://www.ncbi.nlm.nih.gov/pubmed/32565126
http://dx.doi.org/10.1016/j.virusres.2020.198068

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301794/
https://www.ncbi.nlm.nih.gov/pubmed/32565126
http://dx.doi.org/10.1016/j.virusres.2020.198068

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