Shear stimulation of FOXC1 and FOXC2 differentially regulates cytoskeletal activity during lymphatic valve maturation

Mutations in the transcription factor FOXC2 are predominately associated with lymphedema. Herein, we demonstrate a key role for related factor FOXC1, in addition to FOXC2, in regulating cytoskeletal activity in lymphatic valves. FOXC1 is induced by laminar, but not oscillatory, shear and inducible,...

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Detalles Bibliográficos
Autores principales: Norden, Pieter R, Sabine, Amélie, Wang, Ying, Demir, Cansaran Saygili, Liu, Ting, Petrova, Tatiana V, Kume, Tsutomu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302880/
https://www.ncbi.nlm.nih.gov/pubmed/32510325
http://dx.doi.org/10.7554/eLife.53814

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302880/
https://www.ncbi.nlm.nih.gov/pubmed/32510325
http://dx.doi.org/10.7554/eLife.53814

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