GATA4-targeted compound exhibits cardioprotective actions against doxorubicin-induced toxicity in vitro and in vivo: establishment of a chronic cardiotoxicity model using human iPSC-derived cardiomyocytes

Doxorubicin is a widely used anticancer drug that causes dose-related cardiotoxicity. The exact mechanisms of doxorubicin toxicity are still unclear, partly because most in vitro studies have evaluated the effects of short-term high-dose doxorubicin treatments. Here, we developed an in vitro model o...

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Detalles Bibliográficos
Autores principales: Karhu, S. Tuuli, Kinnunen, Sini M., Tölli, Marja, Välimäki, Mika J., Szabó, Zoltán, Talman, Virpi, Ruskoaho, Heikki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Organ Toxicity and Mechanisms
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303099/
https://www.ncbi.nlm.nih.gov/pubmed/32185414
http://dx.doi.org/10.1007/s00204-020-02711-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303099/
https://www.ncbi.nlm.nih.gov/pubmed/32185414
http://dx.doi.org/10.1007/s00204-020-02711-8

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