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The phosphodiesterase-4 and glycine transporter-1 inhibitors enhance in vivo hippocampal theta network connectivity and synaptic plasticity, whereas D-serine does not

Dysfunctional N-methyl-D-aspartate receptors (NMDARs) and cyclic adenosine monophosphate (cAMP) have been associated with deficits in synaptic plasticity and cognition found in neurodegenerative and neuropsychiatric disorders such as Alzheimer’s disease (AD) and schizophrenia. Therapeutic approaches...

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Detalles Bibliográficos
Autores principales: Ahnaou, A., Broadbelt, T., Biermans, R., Huysmans, H., Manyakov, N. V., Drinkenburg, W. H. I. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303193/
https://www.ncbi.nlm.nih.gov/pubmed/32555167
http://dx.doi.org/10.1038/s41398-020-00875-6