Specificity of end resection pathways for double-strand break regions containing ribonucleotides and base lesions

DNA double-strand break repair by homologous recombination begins with nucleolytic resection of the 5’ DNA strand at the break ends. Long-range resection is catalyzed by EXO1 and BLM-DNA2, which likely have to navigate through ribonucleotides and damaged bases. Here, we show that a short stretch of...

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Detalles Bibliográficos
Autores principales: Daley, James M., Tomimatsu, Nozomi, Hooks, Grace, Wang, Weibin, Miller, Adam S., Xue, Xiaoyu, Nguyen, Kevin A., Kaur, Hardeep, Williamson, Elizabeth, Mukherjee, Bipasha, Hromas, Robert, Burma, Sandeep, Sung, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303207/
https://www.ncbi.nlm.nih.gov/pubmed/32555206
http://dx.doi.org/10.1038/s41467-020-16903-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303207/
https://www.ncbi.nlm.nih.gov/pubmed/32555206
http://dx.doi.org/10.1038/s41467-020-16903-4

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