Hemophilia A Inhibitor Subjects Show Unique PBMC Gene Expression Profiles That Include Up-Regulated Innate Immune Modulators

Formation of pathological anti-FVIII antibodies, or “inhibitors,” is the most serious complication of therapeutic FVIII infusions, affecting up to 1/3 of severe Hemophilia A (HA) patients. Inhibitor formation is a classical T-cell dependent adaptive immune response. As such, it requires help from th...

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Detalles Bibliográficos
Autores principales: Karim, Ahmad Faisal, Soltis, Anthony R., Sukumar, Gauthaman, Königs, Christoph, Ewing, Nadia P., Dalgard, Clifton L., Wilkerson, Matthew D., Pratt, Kathleen P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303277/
https://www.ncbi.nlm.nih.gov/pubmed/32595650
http://dx.doi.org/10.3389/fimmu.2020.01219

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303277/
https://www.ncbi.nlm.nih.gov/pubmed/32595650
http://dx.doi.org/10.3389/fimmu.2020.01219

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