Tfam Knockdown Results in Reduction of mtDNA Copy Number, OXPHOS Deficiency and Abnormalities in Zebrafish Embryos

High mitochondrial DNA (mtDNA) copy numbers are essential for oogenesis and embryogenesis and correlate with fertility of oocytes and viability of embryos. To understand the pathology and mechanisms associated with low mtDNA copy numbers, we knocked down mitochondrial transcription factor A (tfam),...

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Detalles Bibliográficos
Autores principales: Otten, Auke B. C., Kamps, Rick, Lindsey, Patrick, Gerards, Mike, Pendeville-Samain, Hélène, Muller, Marc, van Tienen, Florence H. J., Smeets, Hubert J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303330/
https://www.ncbi.nlm.nih.gov/pubmed/32596237
http://dx.doi.org/10.3389/fcell.2020.00381

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303330/
https://www.ncbi.nlm.nih.gov/pubmed/32596237
http://dx.doi.org/10.3389/fcell.2020.00381

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