Selective Inhibition of the Immunoproteasome β5i Prevents PTEN Degradation and Attenuates Cardiac Hypertrophy

Cardiac hypertrophy without appropriate treatment eventually progresses to heart failure. Our recent data demonstrated that the immunoproteasome subunit β5i promotes cardiac hypertrophy. However, whether β5i is a promising therapeutic target for treating hypertrophic remodeling remains unknown. Here...

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Detalles Bibliográficos
Autores principales: Xie, Xin, Wang, Hong-Xia, Li, Nan, Deng, Ya-Wen, Bi, Hai-Lian, Zhang, Yun-Long, Xia, Yun-Long, Li, Hui-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303343/
https://www.ncbi.nlm.nih.gov/pubmed/32595507
http://dx.doi.org/10.3389/fphar.2020.00885

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303343/
https://www.ncbi.nlm.nih.gov/pubmed/32595507
http://dx.doi.org/10.3389/fphar.2020.00885

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