IGAP-integrative genome analysis pipeline reveals new gene regulatory model associated with nonspecific TF-DNA binding affinity

The human genome is regulated in a multi-dimensional way. While biophysical factors like Non-specific Transcription factor Binding Affinity (nTBA) act at DNA sequence level, other factors act above sequence levels such as histone modifications and 3-D chromosomal interactions. This multidimensionali...

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Detalles Bibliográficos
Autores principales: Sahaf Naeini, Alireza, Farooq, Amna, Bjørås, Magnar, Wang, Junbai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303559/
https://www.ncbi.nlm.nih.gov/pubmed/32612751
http://dx.doi.org/10.1016/j.csbj.2020.05.024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303559/
https://www.ncbi.nlm.nih.gov/pubmed/32612751
http://dx.doi.org/10.1016/j.csbj.2020.05.024

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