Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike

There are as yet no licensed therapeutics for the COVID-19 pandemic. The causal coronavirus (SARS-CoV-2) binds host cells via a trimeric spike whose receptor binding domain (RBD) recognizes angiotensin-converting enzyme 2, initiating conformational changes that drive membrane fusion. We find that th...

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Detalles Bibliográficos
Autores principales: Huo, Jiandong, Zhao, Yuguang, Ren, Jingshan, Zhou, Daming, Duyvesteyn, Helen M.E., Ginn, Helen M., Carrique, Loic, Malinauskas, Tomas, Ruza, Reinis R., Shah, Pranav N.M., Tan, Tiong Kit, Rijal, Pramila, Coombes, Naomi, Bewley, Kevin R., Tree, Julia A., Radecke, Julika, Paterson, Neil G., Supasa, Piyada, Mongkolsapaya, Juthathip, Screaton, Gavin R., Carroll, Miles, Townsend, Alain, Fry, Elizabeth E., Owens, Raymond J., Stuart, David I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303615/
https://www.ncbi.nlm.nih.gov/pubmed/32585135
http://dx.doi.org/10.1016/j.chom.2020.06.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303615/
https://www.ncbi.nlm.nih.gov/pubmed/32585135
http://dx.doi.org/10.1016/j.chom.2020.06.010

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