Integrating Systems Biology and an Ex Vivo Human Tumor Model Elucidates PD-1 Blockade Response Dynamics

Ex vivo human tumor models have emerged as promising, yet complex tools to study cancer immunotherapy response dynamics. Here, we present a strategy that integrates empirical data from an ex vivo human system with computational models to interpret the response dynamics of a clinically prescribed PD-...

Descripción completa

Detalles Bibliográficos
Autores principales: Smalley, Munisha, Przedborski, Michelle, Thiyagarajan, Saravanan, Pellowe, Moriah, Verma, Amit, Brijwani, Nilesh, Datta, Debika, Jain, Misti, Shanthappa, Basavaraja U., Kapoor, Vidushi, Gopinath, Kodaganur S., Doval, D.C., Sabitha, K.S., Taroncher-Oldenburg, Gaspar, Majumder, Biswanath, Majumder, Pradip, Kohandel, Mohammad, Goldman, Aaron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303667/
https://www.ncbi.nlm.nih.gov/pubmed/32554190
http://dx.doi.org/10.1016/j.isci.2020.101229

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303667/
https://www.ncbi.nlm.nih.gov/pubmed/32554190
http://dx.doi.org/10.1016/j.isci.2020.101229

Ejemplares similares