Therapeutic Effects of Saline Groundwater Solution Baths on Atopic Dermatitis: A Pilot Study

BACKGROUND: Saline groundwater, collected from the east coast of Korea, has been shown to have protective effects against 2,4-dinitrochlorobenzene- (DNCB-) induced atopic dermatitis-like skin lesions in the murine model. OBJECTIVES: To determine the effects of saline groundwater solution baths as a...

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Autores principales: Yoo, Jisook, Choi, Ji Young, Lee, Bo Young, Shin, Chang Ho, Shin, Jung-Won, Huh, Chang Hun, Na, Jung-Im
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303733/
https://www.ncbi.nlm.nih.gov/pubmed/32595740
http://dx.doi.org/10.1155/2020/8303716
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author Yoo, Jisook
Choi, Ji Young
Lee, Bo Young
Shin, Chang Ho
Shin, Jung-Won
Huh, Chang Hun
Na, Jung-Im
author_facet Yoo, Jisook
Choi, Ji Young
Lee, Bo Young
Shin, Chang Ho
Shin, Jung-Won
Huh, Chang Hun
Na, Jung-Im
author_sort Yoo, Jisook
collection PubMed
description BACKGROUND: Saline groundwater, collected from the east coast of Korea, has been shown to have protective effects against 2,4-dinitrochlorobenzene- (DNCB-) induced atopic dermatitis-like skin lesions in the murine model. OBJECTIVES: To determine the effects of saline groundwater solution baths as a treatment of mild-to-moderate atopic dermatitis. METHODS: Twenty-four subjects with mild-to-moderate atopic dermatitis were instructed to take a bath in saline groundwater solution for 20 minutes per day for two weeks. Evaluations were performed at baseline and week 2, including SCORing Atopic Dermatitis (SCORAD) index, corneometry, transepidermal water loss, visual analogue scale for pruritus, and collection of adverse events. RESULTS: Subjects showed significant improvement with respect to the SCORAD index, skin hydration, transepidermal water loss, and pruritus at week 2 when compared with the baseline. CONCLUSION: Baths in saline groundwater solution may be an alternative therapeutic strategy for treating atopic dermatitis.
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spelling pubmed-73037332020-06-25 Therapeutic Effects of Saline Groundwater Solution Baths on Atopic Dermatitis: A Pilot Study Yoo, Jisook Choi, Ji Young Lee, Bo Young Shin, Chang Ho Shin, Jung-Won Huh, Chang Hun Na, Jung-Im Evid Based Complement Alternat Med Research Article BACKGROUND: Saline groundwater, collected from the east coast of Korea, has been shown to have protective effects against 2,4-dinitrochlorobenzene- (DNCB-) induced atopic dermatitis-like skin lesions in the murine model. OBJECTIVES: To determine the effects of saline groundwater solution baths as a treatment of mild-to-moderate atopic dermatitis. METHODS: Twenty-four subjects with mild-to-moderate atopic dermatitis were instructed to take a bath in saline groundwater solution for 20 minutes per day for two weeks. Evaluations were performed at baseline and week 2, including SCORing Atopic Dermatitis (SCORAD) index, corneometry, transepidermal water loss, visual analogue scale for pruritus, and collection of adverse events. RESULTS: Subjects showed significant improvement with respect to the SCORAD index, skin hydration, transepidermal water loss, and pruritus at week 2 when compared with the baseline. CONCLUSION: Baths in saline groundwater solution may be an alternative therapeutic strategy for treating atopic dermatitis. Hindawi 2020-06-10 /pmc/articles/PMC7303733/ /pubmed/32595740 http://dx.doi.org/10.1155/2020/8303716 Text en Copyright © 2020 Jisook Yoo et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yoo, Jisook
Choi, Ji Young
Lee, Bo Young
Shin, Chang Ho
Shin, Jung-Won
Huh, Chang Hun
Na, Jung-Im
Therapeutic Effects of Saline Groundwater Solution Baths on Atopic Dermatitis: A Pilot Study
title Therapeutic Effects of Saline Groundwater Solution Baths on Atopic Dermatitis: A Pilot Study
title_full Therapeutic Effects of Saline Groundwater Solution Baths on Atopic Dermatitis: A Pilot Study
title_fullStr Therapeutic Effects of Saline Groundwater Solution Baths on Atopic Dermatitis: A Pilot Study
title_full_unstemmed Therapeutic Effects of Saline Groundwater Solution Baths on Atopic Dermatitis: A Pilot Study
title_short Therapeutic Effects of Saline Groundwater Solution Baths on Atopic Dermatitis: A Pilot Study
title_sort therapeutic effects of saline groundwater solution baths on atopic dermatitis: a pilot study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303733/
https://www.ncbi.nlm.nih.gov/pubmed/32595740
http://dx.doi.org/10.1155/2020/8303716
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