Targeted Degradation of SLC Transporters Reveals Amenability of Multi-Pass Transmembrane Proteins to Ligand-Induced Proteolysis

With more than 450 members, the solute carrier (SLC) group of proteins represents the largest class of transporters encoded in the human genome. Their several-pass transmembrane domain structure and hydrophobicity contribute to the orphan status of many SLCs, devoid of known cargos or chemical inhib...

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Detalles Bibliográficos
Autores principales: Bensimon, Ariel, Pizzagalli, Mattia D., Kartnig, Felix, Dvorak, Vojtech, Essletzbichler, Patrick, Winter, Georg E., Superti-Furga, Giulio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303955/
https://www.ncbi.nlm.nih.gov/pubmed/32386596
http://dx.doi.org/10.1016/j.chembiol.2020.04.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303955/
https://www.ncbi.nlm.nih.gov/pubmed/32386596
http://dx.doi.org/10.1016/j.chembiol.2020.04.003

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