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Conjugated Protein Domains as Engineered Scaffold Proteins

[Image: see text] Assembly of proteins into higher-order complexes generates specificity and selectivity in cellular signaling. Signaling complex formation is facilitated by scaffold proteins that use modular scaffolding domains, which recruit specific pathway enzymes. Multimerization and recombinat...

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Detalles Bibliográficos
Autores principales: Lemmens, Lenne J. M., Ottmann, Christian, Brunsveld, Luc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303964/
https://www.ncbi.nlm.nih.gov/pubmed/32374984
http://dx.doi.org/10.1021/acs.bioconjchem.0c00183