Therapy-induced lipid uptake and remodeling underpin ferroptosis hypersensitivity in prostate cancer

BACKGROUND: Metabolic reprograming, non-mutational epigenetic changes, increased cell plasticity, and multidrug tolerance are early hallmarks of therapy resistance in cancer. In this temporary, therapy-tolerant state, cancer cells are highly sensitive to ferroptosis, a form of regulated cell death t...

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Detalles Bibliográficos
Autores principales: Tousignant, Kaylyn D., Rockstroh, Anja, Poad, Berwyck L. J., Talebi, Ali, Young, Reuben S. E., Taherian Fard, Atefeh, Gupta, Rajesh, Zang, Tuo, Wang, Chenwei, Lehman, Melanie L., Swinnen, Johan V., Blanksby, Stephen J., Nelson, Colleen C., Sadowski, Martin C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304214/
https://www.ncbi.nlm.nih.gov/pubmed/32577235
http://dx.doi.org/10.1186/s40170-020-00217-6

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