Effects of DNA topoisomerase IIα splice variants on acquired drug resistance

DNA topoisomerase IIα (170 kDa, TOP2α/170) induces transient DNA double-strand breaks in proliferating cells to resolve DNA topological entanglements during chromosome condensation, replication, and segregation. Therefore, TOP2α/170 is a prominent target for anticancer drugs whose clinical efficacy...

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Detalles Bibliográficos
Autores principales: Elton, Terry S., Ozer, Hatice Gulcin, Yalowich, Jack C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: OAE Publishing Inc. 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304410/
https://www.ncbi.nlm.nih.gov/pubmed/32566920
http://dx.doi.org/10.20517/cdr.2019.117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304410/
https://www.ncbi.nlm.nih.gov/pubmed/32566920
http://dx.doi.org/10.20517/cdr.2019.117

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