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Effects of DNA topoisomerase IIα splice variants on acquired drug resistance

DNA topoisomerase IIα (170 kDa, TOP2α/170) induces transient DNA double-strand breaks in proliferating cells to resolve DNA topological entanglements during chromosome condensation, replication, and segregation. Therefore, TOP2α/170 is a prominent target for anticancer drugs whose clinical efficacy...

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Detalles Bibliográficos
Autores principales:	Elton, Terry S., Ozer, Hatice Gulcin, Yalowich, Jack C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	OAE Publishing Inc. 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304410/ https://www.ncbi.nlm.nih.gov/pubmed/32566920 http://dx.doi.org/10.20517/cdr.2019.117

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