Multiple myeloma: Combination therapy of BET proteolysis targeting chimeric molecule with CDK9 inhibitor

Cyclin Dependent Kinase 9 (CDK9) associates with Bromodomain and Extra-Terminal Domain (BET) proteins to promote transcriptional elongation by phosphorylation of serine 2 of RNAP II C-terminal domain. We examined the therapeutic potential of selective CDK9 inhibitors (AZD 4573 and MC180295) against...

Descripción completa

Detalles Bibliográficos
Autores principales: Lim, Su-Lin, Xu, Liang, Han, Bing-Chen, Shyamsunder, Pavithra, Chng, Wee-Joo, Koeffler, H. Phillip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304913/
https://www.ncbi.nlm.nih.gov/pubmed/32559187
http://dx.doi.org/10.1371/journal.pone.0232068

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304913/
https://www.ncbi.nlm.nih.gov/pubmed/32559187
http://dx.doi.org/10.1371/journal.pone.0232068

Ejemplares similares