Nuclear softening expedites interstitial cell migration in fibrous networks and dense connective tissues

Dense matrices impede interstitial cell migration and subsequent repair. We hypothesized that nuclear stiffness is a limiting factor in migration and posited that repair could be expedited by transiently decreasing nuclear stiffness. To test this, we interrogated the interstitial migratory capacity...

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Detalles Bibliográficos
Autores principales: Heo, Su-Jin, Song, Kwang Hoon, Thakur, Shreyasi, Miller, Liane M., Cao, Xuan, Peredo, Ana P., Seiber, Breanna N., Qu, Feini, Driscoll, Tristan P., Shenoy, Vivek B., Lakadamyali, Melike, Burdick, Jason A., Mauck, Robert L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304973/
https://www.ncbi.nlm.nih.gov/pubmed/32596438
http://dx.doi.org/10.1126/sciadv.aax5083

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