Long-distance modulation of bystander tumor cells by CD8(+) T cell-secreted IFNγ

T cell-secreted IFNγ can exert pleiotropic effects on tumor cells that include induction of immune checkpoints and antigen presentation machinery components, and inhibition of cell growth. Despite its role as key effector molecule, little is known about the spatiotemporal spreading of IFNγ secreted...

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Detalles Bibliográficos
Autores principales: Hoekstra, Mirjam E., Bornes, Laura, Dijkgraaf, Feline E., Philips, Daisy, Pardieck, Iris N., Toebes, Mireille, Thommen, Daniela S., van Rheenen, Jacco, Schumacher, Ton N.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305033/
https://www.ncbi.nlm.nih.gov/pubmed/32566933
http://dx.doi.org/10.1038/s43018-020-0036-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305033/
https://www.ncbi.nlm.nih.gov/pubmed/32566933
http://dx.doi.org/10.1038/s43018-020-0036-4

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