Leucine regulates autophagy via acetylation of the mTORC1 component raptor

Macroautophagy (“autophagy”) is the main lysosomal catabolic process that becomes activated under nutrient-depleted conditions, like amino acid (AA) starvation. The mechanistic target of rapamycin complex 1 (mTORC1) is a well-conserved negative regulator of autophagy. While leucine (Leu) is a critic...

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Detalles Bibliográficos
Autores principales: Son, Sung Min, Park, So Jung, Stamatakou, Eleanna, Vicinanza, Mariella, Menzies, Fiona M., Rubinsztein, David C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305105/
https://www.ncbi.nlm.nih.gov/pubmed/32561715
http://dx.doi.org/10.1038/s41467-020-16886-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305105/
https://www.ncbi.nlm.nih.gov/pubmed/32561715
http://dx.doi.org/10.1038/s41467-020-16886-2

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