MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis

Mixed lineage kinase domain-like (MLKL) is the terminal protein in the pro-inflammatory necroptotic cell death program. RIPK3-mediated phosphorylation is thought to initiate MLKL oligomerization, membrane translocation and membrane disruption, although the precise choreography of events is incomplet...

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Detalles Bibliográficos
Autores principales: Samson, Andre L., Zhang, Ying, Geoghegan, Niall D., Gavin, Xavier J., Davies, Katherine A., Mlodzianoski, Michael J., Whitehead, Lachlan W., Frank, Daniel, Garnish, Sarah E., Fitzgibbon, Cheree, Hempel, Anne, Young, Samuel N., Jacobsen, Annette V., Cawthorne, Wayne, Petrie, Emma J., Faux, Maree C., Shield-Artin, Kristy, Lalaoui, Najoua, Hildebrand, Joanne M., Silke, John, Rogers, Kelly L., Lessene, Guillaume, Hawkins, Edwin D., Murphy, James M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305196/
https://www.ncbi.nlm.nih.gov/pubmed/32561730
http://dx.doi.org/10.1038/s41467-020-16887-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305196/
https://www.ncbi.nlm.nih.gov/pubmed/32561730
http://dx.doi.org/10.1038/s41467-020-16887-1

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