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Highly parallel lab evolution reveals that epistasis can curb the evolution of antibiotic resistance
Genetic perturbations that affect bacterial resistance to antibiotics have been characterized genome-wide, but how do such perturbations interact with subsequent evolutionary adaptation to the drug? Here, we show that strong epistasis between resistance mutations and systematically identified genes...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305214/ https://www.ncbi.nlm.nih.gov/pubmed/32561723 http://dx.doi.org/10.1038/s41467-020-16932-z |