Enhancement of dissolution of atorvastatin through preparation of polymeric solid dispersions using supercritical fluid technology

BACKGROUND AND PURPOSE: This study aimed at preparation of solid dispersions in order to enhance dissolution of poorly water-soluble atorvastatin using supercritical CO2 technology. Atorvastatin has poor bioavailability of 12%, mainly due to poor water solubility and dissolution. Dispersion of drugs...

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Detalles Bibliográficos
Autores principales: Altaani, Bashar, Obaidat, Rana, Malkawi, Walaa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306245/
https://www.ncbi.nlm.nih.gov/pubmed/32582352
http://dx.doi.org/10.4103/1735-5362.283812

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306245/
https://www.ncbi.nlm.nih.gov/pubmed/32582352
http://dx.doi.org/10.4103/1735-5362.283812

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