Targeting of cholera toxin A (ctxA) gene by zinc finger nuclease: pitfalls of using gene editing tools in prokaryotes

BACKGROUND AND PURPOSE: The study was launched to use zinc finger nuclease (ZFN) technology to disrupt the cholera toxin gene (ctxA) for inhibiting CT toxin production in Vibrio cholera (V. cholera). EXPERIMENTAL APPROACH: An engineered ZFN was designed to target the catalytic site of the ctxA gene....

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Detalles Bibliográficos
Autores principales: Hosseini, Nafiseh, Khanahmad, Hossein, Esfahani, Bahram Nasr, Bandehpour, Mojgan, Shariati, Laleh, Zahedi, Nushin, Kazemi, Bahram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306252/
https://www.ncbi.nlm.nih.gov/pubmed/32582358
http://dx.doi.org/10.4103/1735-5362.283818

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306252/
https://www.ncbi.nlm.nih.gov/pubmed/32582358
http://dx.doi.org/10.4103/1735-5362.283818

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