Dedifferentiation: the return road to repair the intestinal epithelium

In the March 5 issue of Cell Stem Cell, (Murata K et al. Cell Stem Cell. 26(377–390):e376 2020) reported that intestinal stem cell recovery after injury is principally through Ascl2-dependent dedifferentiation of absorptive and secretory precursors in mice. This study provides evidence for robust re...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Yuan, Xiong, Xiaochen, Chen, Ye-Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306829/
https://www.ncbi.nlm.nih.gov/pubmed/32588148
http://dx.doi.org/10.1186/s13619-020-00048-2
Descripción
Sumario:In the March 5 issue of Cell Stem Cell, (Murata K et al. Cell Stem Cell. 26(377–390):e376 2020) reported that intestinal stem cell recovery after injury is principally through Ascl2-dependent dedifferentiation of absorptive and secretory precursors in mice. This study provides evidence for robust regenerative capability of the intestinal epithelium via dedifferentiation of absorptive and secretory progenitors in the crypt.

Ejemplares similares