Dedifferentiation: the return road to repair the intestinal epithelium

In the March 5 issue of Cell Stem Cell, (Murata K et al. Cell Stem Cell. 26(377–390):e376 2020) reported that intestinal stem cell recovery after injury is principally through Ascl2-dependent dedifferentiation of absorptive and secretory precursors in mice. This study provides evidence for robust re...

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Autores principales: Liu, Yuan, Xiong, Xiaochen, Chen, Ye-Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306829/
https://www.ncbi.nlm.nih.gov/pubmed/32588148
http://dx.doi.org/10.1186/s13619-020-00048-2
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author Liu, Yuan
Xiong, Xiaochen
Chen, Ye-Guang
author_facet Liu, Yuan
Xiong, Xiaochen
Chen, Ye-Guang
author_sort Liu, Yuan
collection PubMed
description In the March 5 issue of Cell Stem Cell, (Murata K et al. Cell Stem Cell. 26(377–390):e376 2020) reported that intestinal stem cell recovery after injury is principally through Ascl2-dependent dedifferentiation of absorptive and secretory precursors in mice. This study provides evidence for robust regenerative capability of the intestinal epithelium via dedifferentiation of absorptive and secretory progenitors in the crypt.
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spelling pubmed-73068292020-06-23 Dedifferentiation: the return road to repair the intestinal epithelium Liu, Yuan Xiong, Xiaochen Chen, Ye-Guang Cell Regen Research Highlight In the March 5 issue of Cell Stem Cell, (Murata K et al. Cell Stem Cell. 26(377–390):e376 2020) reported that intestinal stem cell recovery after injury is principally through Ascl2-dependent dedifferentiation of absorptive and secretory precursors in mice. This study provides evidence for robust regenerative capability of the intestinal epithelium via dedifferentiation of absorptive and secretory progenitors in the crypt. Springer Singapore 2020-06-02 /pmc/articles/PMC7306829/ /pubmed/32588148 http://dx.doi.org/10.1186/s13619-020-00048-2 Text en © The Author(s) 2021, corrected publication 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Highlight
Liu, Yuan
Xiong, Xiaochen
Chen, Ye-Guang
Dedifferentiation: the return road to repair the intestinal epithelium
title Dedifferentiation: the return road to repair the intestinal epithelium
title_full Dedifferentiation: the return road to repair the intestinal epithelium
title_fullStr Dedifferentiation: the return road to repair the intestinal epithelium
title_full_unstemmed Dedifferentiation: the return road to repair the intestinal epithelium
title_short Dedifferentiation: the return road to repair the intestinal epithelium
title_sort dedifferentiation: the return road to repair the intestinal epithelium
topic Research Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306829/
https://www.ncbi.nlm.nih.gov/pubmed/32588148
http://dx.doi.org/10.1186/s13619-020-00048-2
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AT chenyeguang dedifferentiationthereturnroadtorepairtheintestinalepithelium

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